VDR is a gene that encodes a vitamin D receptor protein. This protein regulates calcium absorption as well as bone development. A variant of the gene, rs2228570 (FokI polymorphism) is associated with reduced bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and geschaeftsmarketingstrategie can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time off-and-on occupancy of the VDRE between the two components. It is also influenced by chromosomal positioning and binding preferences for specific hormones. Microarray studies of human cells show that over 100 genes have a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can be an archive of information and documents relevant to legal, business transactions, or processes. Viewing, downloading or printing are restricted. It utilizes a central server and an extranet connection, which is an Internet connection with restricted access, to offer controlled access to users at specific times at which users can access the data and documents.
VDRs are typically used by investment banks and companies involved in mergers or acquisitions. They must be able to communicate information in a clear way with potential investors or buyers. Due diligence can also require a substantial amount of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.